Preconditioning Local Injection of Activated Platelet-Rich Plasma Increases Angiogenesis, VEGF Levels, and Viability of Modified McFarlane Flap in Diabetes-Induced Rats

Preconditioning Local Injection of Activated Platelet-Rich Plasma Increases Angiogenesis, VEGF Levels, and Viability of Modified McFarlane Flap in Diabetes-Induced Rats

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Background The risk of flap necrosis in tissue reconstruction surgery is elevated in patients with vascular disorders, such as diabetes mellitus.Chronic hyperglycemia causes endothelial cell SUPER MULTI-WITH IRON dysfunction and increases inflammatory process, causing vascular insufficiency.Platelet-rich plasma (PRP) contains high levels of platelets, growth factors, and fibrinogens.Its regenerative properties Baby Strollers spark interest in supporting flap survival in relation to diabetic complications.